Crystal Structure and NMR of an α,δ‐Peptide Foldamer Helix Shows Side‐Chains are Well Placed for Bifunctional Catalysis: Application as a Minimalist Aldolase Mimic

A helical catalyst that is constructed from α- and δ-amino acids: In their Research Article (e202305326), Alexander J. A. Cobb et al. present a foldamer helix whereby the catalytic functionalities are positioned in such way they can be exploited for bifunctional catalysis. The stability of modularity system (represented by jigsaw pieces) means different α-amino acids used whilst maintaining same type. described acts as an aldolase (where molecule essentially split into two depicted graphic).